2,235 research outputs found
Evolving graphs: dynamical models, inverse problems and propagation
Applications such as neuroscience, telecommunication, online social networking,
transport and retail trading give rise to connectivity patterns that change over time.
In this work, we address the resulting need for network models and computational
algorithms that deal with dynamic links. We introduce a new class of evolving
range-dependent random graphs that gives a tractable framework for modelling and
simulation. We develop a spectral algorithm for calibrating a set of edge ranges from
a sequence of network snapshots and give a proof of principle illustration on some
neuroscience data. We also show how the model can be used computationally and
analytically to investigate the scenario where an evolutionary process, such as an
epidemic, takes place on an evolving network. This allows us to study the cumulative
effect of two distinct types of dynamics
Parallel Load Balancing on constrained client-server topologies
We study parallel Load Balancing protocols for the client-server distributed model defined as follows. There is a set of n clients and a set
of n servers where each client has (at most) a constant number of requests that must be assigned to some server. The client set and the server one are connected to each other via a fixed bipartite graph: the requests of client v can only be sent to the servers in its neighborhood. The goal is to assign every client request so as to minimize the maximum load of the servers.
In this setting, efficient parallel protocols are available only for dense topologies. In particular, a simple protocol, named raes, has been recently introduced by Becchetti et al. [1] for regular dense bipartite graphs. They show that this symmetric, non-adaptive protocol achieves constant maximum load with parallel completion time
and overall work, w.h.p.
Motivated by proximity constraints arising in some client-server systems, we analyze raes over almost-regular bipartite graphs where nodes may have neighborhoods of small size. In detail, we prove that, w.h.p., the raes protocol keeps the same performances as above (in terms of maximum load, completion time, and work complexity, respectively) on any almost-regular bipartite graph with degree.
Our analysis significantly departs from that in [1] since it requires to cope with non-trivial stochastic-dependence issues on the random choices of the algorithmic process which are due to the worst-case, sparse topology of the underlying graph
Deterministic Digital Clustering of Wireless Ad Hoc Networks
We consider deterministic distributed communication in wireless ad hoc
networks of identical weak devices under the SINR model without predefined
infrastructure. Most algorithmic results in this model rely on various
additional features or capabilities, e.g., randomization, access to geographic
coordinates, power control, carrier sensing with various precision of
measurements, and/or interference cancellation. We study a pure scenario, when
no such properties are available. As a general tool, we develop a deterministic
distributed clustering algorithm. Our solution relies on a new type of
combinatorial structures (selectors), which might be of independent interest.
Using the clustering, we develop a deterministic distributed local broadcast
algorithm accomplishing this task in rounds, where
is the density of the network. To the best of our knowledge, this is
the first solution in pure scenario which is only polylog away from the
universal lower bound , valid also for scenarios with
randomization and other features. Therefore, none of these features
substantially helps in performing the local broadcast task. Using clustering,
we also build a deterministic global broadcast algorithm that terminates within
rounds, where is the diameter of the
network. This result is complemented by a lower bound , where is the path-loss parameter of the
environment. This lower bound shows that randomization or knowledge of own
location substantially help (by a factor polynomial in ) in the global
broadcast. Therefore, unlike in the case of local broadcast, some additional
model features may help in global broadcast
POINT CLOUD EXPLOITATION FOR STRUCTURAL MODELING AND ANALYSIS: A RELIABLE WORKFLOW
none4noThe digitization and geometric knowledge of the historical built heritage is currently based on point cloud, that rarely or only partially is used as digital twin for structural analysis. The present work deals with historical artefacts survey, with particular reference to masonry structures, aimed to their structural analysis and assessment. In detail, the study proposes a methodology capable of employing semi-directly the original data obtained from the 3D digital survey for the generation of a Finite Element Model (FEM), used for structural analysis of masonry buildings.
The methodology described presents a reliable workflow with twofold purpose: the improvement of the transformation process of the point cloud in solid and subsequently obtain a high-quality and detailed model for structural analyses.
Through the application of the methodology to a case study, the method consistency was assessed, regarding the smoothness of the whole procedure and the dynamic characterization of the Finite Element Model. The main improvement in respect with similar or our previous workflows is obtained by the introduction of the retopology in data processing, allowing the transformation of the raw data into a solid model with optimal balancing between Level of Detail (LOD) and computational weight. Another significant aspect of the optimized process is undoubtedly the possibility of faithfully respecting the semantics of the structure, leading to the discretization of the model into different parts depending on the materials. This work may represent an excellent reference for the study of masonry artefacts belonging to the existing historical heritage, starting from surveys and with the purpose to structural and seismic evaluations, in the general framework of knowledge-based preservation of heritage.openLucidi, A.; Giordano, E.; Clementi, F.; Quattrini, R.Lucidi, A.; Giordano, E.; Clementi, F.; Quattrini, R
Finding a Bounded-Degree Expander Inside a Dense One
It follows from the Marcus-Spielman-Srivastava proof of the Kadison-Singer conjecture that if is a -regular dense expander then there is an edge-induced subgraph of of constant maximum degree which is also an expander. As with other consequences of the MSS theorem, it is not clear how one would explicitly construct such a subgraph. We show that such a subgraph (although with quantitatively weaker expansion and near-regularity properties than those predicted by MSS) can be constructed with high probability in linear time, via a simple algorithm. Our algorithm allows a distributed implementation that runs in rounds and does \bigO(n) total work with high probability. The analysis of the algorithm is complicated by the complex dependencies that arise between edges and between choices made in different rounds. We sidestep these difficulties by following the combinatorial approach of counting the number of possible random choices of the algorithm which lead to failure. We do so by a compression argument showing that such random choices can be encoded with a non-trivial compression. Our algorithm bears some similarity to the way agents construct a communication graph in a peer-to-peer network, and, in the bipartite case, to the way agents select servers in blockchain protocols
Naringenin is a powerful inhibitor of SARS-CoV-2 infection in vitro
Recently, an interesting review appeared in Pharmacological Research presented a list of candidate drugs against SARS-CoV-2 and COVID-19 [1]. In the present insight, we highlight novel experimental evidence that the flavanone Naringenin, targeting the endo-lysosomal Two-Pore Channels (TPCs), could be added to the list of potential weapons against SARS-CoV-2 infection and COVID-19 disease
Parameterized optimized effective potential for the ground state of the atoms He through Xe
Parameterized orbitals expressed in Slater-type basis obtained within the
optimized effective potential framework as well as the parameterization of the
potential are reported for the ground state of the atoms He through Xe. The
total, kinetic, exchange and single particle energies are given for each atom.Comment: 47 pages, 1 figur
Large-Scale Structure-Based Prediction of Stable Peptide Binding to Class I HLAs Using Random Forests
Prediction of stable peptide binding to Class I HLAs is an important component for designing immunotherapies. While the best performing predictors are based on machine learning algorithms trained on peptide-HLA (pHLA) sequences, the use of structure for training predictors deserves further exploration. Given enough pHLA structures, a predictor based on the residue-residue interactions found in these structures has the potential to generalize for alleles with little or no experimental data. We have previously developed APE-Gen, a modeling approach able to produce pHLA structures in a scalable manner. In this work we use APE-Gen to model over 150,000 pHLA structures, the largest dataset of its kind, which were used to train a structure-based pan-allele model. We extract simple, homogenous features based on residue-residue distances between peptide and HLA, and build a random forest model for predicting stable pHLA binding. Our model achieves competitive AUROC values on leave-one-allele-out validation tests using significantly less data when compared to popular sequence-based methods. Additionally, our model offers an interpretation analysis that can reveal how the model composes the features to arrive at any given prediction. This interpretation analysis can be used to check if the model is in line with chemical intuition, and we showcase particular examples. Our work is a significant step toward using structure to achieve generalizable and more interpretable prediction for stable pHLA binding
The Coulomb Interaction between Pion-Wavepackets: The piplus-piminus Puzzle
The time dependent Schr\"odinger equation for -- pairs, which
are emitted from the interaction zone in relativistic nuclear collisions, is
solved using wavepacket states. It is shown that the Coulomb enhancement in the
momentum correlation function of such pairs is smaller than obtained in earlier
calculations based on Coulomb distorted plane waves. These results suggest that
the experimentally observed positive correlation signal cannot be caused by the
Coulomb interaction between pions emitted from the interaction zone. But other
processes which involve long-lived resonances and the related extended source
dimensions could provide a possible explanation for the observed signal.Comment: 12 pages, LaTeX, 1 figur
Kappa-deformed random-matrix theory based on Kaniadakis statistics
We present a possible extension of the random-matrix theory, which is widely
used to describe spectral fluctuations of chaotic systems. By considering the
Kaniadakis non-Gaussian statistics, characterized by the index {\kappa}
(Boltzmann-Gibbs entropy is recovered in the limit {\kappa}\rightarrow0), we
propose the non-Gaussian deformations ({\kappa} \neq 0) of the conventional
orthogonal and unitary ensembles of random matrices. The joint eigenvalue
distributions for the {\kappa}-deformed ensembles are derived by applying the
principle maximum entropy to Kaniadakis entropy. The resulting distribution
functions are base invarient as they depend on the matrix elements in a trace
form. Using these expressions, we introduce a new generalized form of the
Wigner surmise valid for nearly-chaotic mixed systems, where a
basis-independent description is still expected to hold. We motivate the
necessity of such generalization by the need to describe the transition of the
spacing distribution from chaos to order, at least in the initial stage. We
show several examples about the use of the generalized Wigner surmise to the
analysis of the results of a number of previous experiments and numerical
experiments. Our results suggest the entropic index {\kappa} as a measure for
deviation from the state of chaos. We also introduce a {\kappa}-deformed
Porter-Thomas distribution of transition intensities, which fits the
experimental data for mixed systems better than the commonly-used
gamma-distribution.Comment: 18 pages, 8 figure
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